Pemphigus foliaceus associated with Hypericum perforatum

CYP: cytochrome P INTRODUCTION Pemphigus foliaceus is a rare autoimmune bullous dermatosis that can be induced by drugs, with variable duration lasting between several weeks and months. Erythematous scaly patches develop on the scalp, face, neck or chest. The use of oral or topical herbal supplements to improve health has increased in the last decades. These preparations may trigger multiple adverse effects, both cutaneous and systematic. Hypericum perforatum (popularly known as St. John’s wort) is an herbal drug with a widely known photosensitizing effect and a possible immunomodulatory effect.